Location the combination within a container such as a sealed plastic bag and throw it away inside the household trash. You can even adhere to your state or local rules on how to safely and securely toss away Promethazine Hydrochloride and Codeine Phosphate Oral Solution.

Hyperexcitability and irregular movements happen to be documented in patients next one administration of promethazine HCl. Thought ought to be specified to your discontinuation of promethazine HCl and to using other medicines if these reactions occur.

Antiemetics will not be encouraged for cure of uncomplicated vomiting in pediatric patients, and their use should be restricted to prolonged vomiting of acknowledged etiology. The extrapyramidal indicators which may happen secondary to Promethazine HCl Oral Solution administration may very well be perplexed While using the CNS signs of undiagnosed primary disease, e.g., encephalopathy or Reye's syndrome. The use of Promethazine HCl Oral Resolution need to be avoided in pediatric clients whose indications and indications might suggest Reye's syndrome or other hepatic ailments.

Concomitant administration of promethazine merchandise with other respiratory depressants has an association with respiratory despair, and occasionally Loss of life, in pediatric patients.

Daily life-threatening respiratory depression and Loss of life have occurred in little ones who received codeine; most conditions adopted tonsillectomy and/or adenoidectomy, and many of the kids experienced proof of being an ultra-quick metabolizer of codeine because of a CYP2D6 polymorphism. (five.three) Promethazine HCl and Codeine Phosphate Oral Solution is contraindicated in youngsters younger than 12 several years of age As well as in little ones younger than 18 yrs of age following tonsillectomy and/or adenoidectomy.

, ritonavir) or discontinuation of the cytochrome P450 3A4 inducer like rifampin, carbamazepine, and phenytoin, may perhaps cause a rise in codeine plasma concentrations with subsequently greater metabolism by cytochrome P450 2D6, causing better morphine amounts, which could maximize or extend adverse reactions and should result in possibly lethal respiratory depression.

Normal Grownup dosage is 50 mg Promethazine using an properly diminished dose of narcotic or barbiturate as well as required amount of a belladonna alkaloid.

Codeine in oral therapeutic dosage will not usually exert major effects within the cardiovascular method.

Acute or severe bronchial bronchial asthma in an unmonitored setting or in absence of resuscitative products. (four)

The respiratory depression requires a discount while in the responsiveness with the brain stem respiratory centers to both of those improves in carbon dioxide tension also to electrical stimulation.

The standard effective dose of Promethazine for your Energetic therapy of nausea and vomiting in little ones or Older people is twenty five mg.

Pediatric people should be supervised in order to avoid potential hurt in bike Using or in other hazardous pursuits.

Mainly because opioid agonists may possibly improve biliary tract force, with resultant boost in plasma amylase or read more lipase stages, resolve of those enzyme stages may be unreliable for twenty-four hrs right after administration of a dose of Promethazine HCl and Codeine Phosphate Oral Option.

Promethazine HCl Oral Solution can be utilized by yourself or being an adjunct to narcotic analgesics throughout labor (see DOSAGE AND ADMINISTRATION). Minimal data propose that utilization of Promethazine HCl Oral Solution in the course of labor and shipping doesn't have an considerable effect on the duration of labor or shipping and delivery and isn't going to enhance the danger of need to have for intervention during the new child.